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KMID : 0438219770140020303
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Korea University Medical Journal
1977 Volume.14 No. 2 p.303 ~ p.313
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The Effect of Vitamin E on Human Blood, in vivo and vitro, Its Components and Osmotic Resistance
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Abstract
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The Effect of Vitamin E on Human Blood, in vivo and vitro,
Its Components and Osmotic Resistance
Bok Young Rha, M. D. and Yong Hyuck Chun, M. D.
Department of Anatomy, Korea University College of Medicine
Seoul, Korea
The effects of vitamin E, parenteral administration and supplement in vitro to human blood - its components and osmotic resistance - were studied.
Blood samples were collected from 12 normal abult volunteers and afterward vitamin E was administered on a daily dose of 200 I. U. for 90 days. In vitro test, 0.1 mg of dl-alpha-tocopheryl acetate was added on each ml of blood specimens.
Hematological values were calculated and osmotic fragility was measured by Dacie´s method for 25 days at 5-day intervals.
The following results were obtained.
1. It was observed that vitamin E supplement in human ACD-blood in storage at 4C greatly retarded the rate of decrease in osmotic resistance of erythrocytes.
2. RBC fragility was sensitive to temperature that exposure at 37C for 6 hours accelerated the hemolysis and it was markedly suppressed by vitamin E supplement.
3. Parenteral adminstration of vitamin E resulted in increased values for total red cell counts, hemoglobin, hematocrit and reticulocytes, while platelet counts were decreased comparing with that of normal control. Concerning RBC fragility, no indication of prevention to hemo?y its was observed.
4. Therefore, it is emphasized that, vitamin E supplement into the stored blood is definitely effective to red cell survival and it is recommendable for the blood storing in long term preservation especially under the inadequate temperature.
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